2，4-二甲氧基-5-硝基苯甲酸合成路线 （共 12 条）
反应条件
sodium hydroxide in methanol; water
Hydrolysis; Heating;
参考文献
Zhu, Jin; Parra, Ruben D.; Zeng, Huaqiang; Skrzypczak-Jankun, Ewa; Zeng, Xiao Cheng; Gong, Bing
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4219 - 4220
反应条件
ammonium cerium(IV) nitrate in acetonitrile
T=80 - 85°C; 0.25 h;
参考文献
Chawla, H. Mohindra; Mittal, Ram S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 11 p. 1129 - 1131
反应条件
1: 72 percent / nitric acid; acetic acid / 12 h / 20 °C
2: 64.4 percent / sulfuric acid / Heating
3: 50 percent / potassium carbonate / dimethylformamide / 72 h / 100 °C
4: 96 percent / sodium hydroxide / methanol; H2O / Heating
View Scheme
参考文献
Zhu, Jin; Parra, Ruben D.; Zeng, Huaqiang; Skrzypczak-Jankun, Ewa; Zeng, Xiao Cheng; Gong, Bing
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4219 - 4220
反应条件
1: 64.4 percent / sulfuric acid / Heating
2: 50 percent / potassium carbonate / dimethylformamide / 72 h / 100 °C
3: 96 percent / sodium hydroxide / methanol; H2O / Heating
View Scheme
参考文献
Zhu, Jin; Parra, Ruben D.; Zeng, Huaqiang; Skrzypczak-Jankun, Ewa; Zeng, Xiao Cheng; Gong, Bing
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4219 - 4220
反应条件
1: 50 percent / potassium carbonate / dimethylformamide / 72 h / 100 °C
2: 96 percent / sodium hydroxide / methanol; H2O / Heating
View Scheme
参考文献
Zhu, Jin; Parra, Ruben D.; Zeng, Huaqiang; Skrzypczak-Jankun, Ewa; Zeng, Xiao Cheng; Gong, Bing
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4219 - 4220
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5686482 A1, 1997 ;
反应条件
ammonium cerium(IV) nitrate; trifluoroacetic acid
T=23°C; 1 h; Yields of byproduct given;
参考文献
Peterson, John R.; Do, Hoang D.; Dunham, Andrew J.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 1670 - 1674
参考文献
Goldstein; Jaquet
Helvetica Chimica Acta, 1941 , vol. 24, p. 30,37
反应条件
1: aqueous potassium permanganate
2: nitric acid; sulfuric acid
3: methanol. KOH-solution
View Scheme
参考文献
Goldstein; Jaquet
Helvetica Chimica Acta, 1941 , vol. 24, p. 30,37
反应条件
2: methanol. KOH
View Scheme
参考文献
Goldstein; Urvater
Helvetica Chimica Acta, 1951 , vol. 34, p. 1350,1354
