3-氨基-5-硝基苯甲醇合成路线 （共 10 条）
反应条件
(NH4)2S in methanol Heating;
参考文献
Campbell, Robert F.; Fitzpatrick, Kevin; Inghardt, Tord; Karlsson, Olle; Nilsson, Kristina; Reilly, John E.; Yet, Larry
Tetrahedron Letters, 2003 , vol. 44, # 29 p. 5477 - 5481
反应条件
1: 89 percent / BH3*THF / tetrahydrofuran / 0 - 25 °C 2: 88 percent / (NH4)2S / methanol / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 29 p. 5477 - 5481
反应条件
1: 1.) HNO2, 2.) CuCl2, CuCl, 12percent aq. HCl / 1.) 0 deg C, 2.) 60 deg C, 1 h 2: 81 percent / Fe, HCl (gas) / ethanol 3: 65 percent / aq. HBF4, NaNO2 / -5 °C 4: 25 percent / Heating 5: 73 percent / MnO2 / benzene / 24 h / Heating View Scheme
参考文献
Meindl; Von Angerer; Schonenberger; Ruckdeschel
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1111 - 1118
反应条件
1: 1.) HNO2, 2.) CuCl2, CuCl, 12percent aq. HCl / 1.) 0 deg C, 2.) 60 deg C, 1 h 2: 81 percent / Fe, HCl (gas) / ethanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
反应条件
1: 1.) HNO2, 2.) CuCl2, CuCl, 12percent aq. HCl / 1.) 0 deg C, 2.) 60 deg C, 1 h 2: 81 percent / Fe, HCl (gas) / ethanol 3: 65 percent / aq. HBF4, NaNO2 / -5 °C 4: 25 percent / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
反应条件
1: aq. NaNO2; HCl; CuCl2 / 60 °C 2: MnO2 / CH2Cl2 / 25 °C View Scheme
参考文献
Meindl; Von Angerer; Schonenberger; Ruckdeschel
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1111 - 1118
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=-5°C;
2: With hydrogenchloride; copper(l) chloride; copper dichloride in water
T=-5 - 65°C;
参考文献
Campbell, Robert F.; Fitzpatrick, Kevin; Inghardt, Tord; Karlsson, Olle; Nilsson, Kristina; Reilly, John E.; Yet, Larry
Tetrahedron Letters, 2003 , vol. 44, # 29 p. 5477 - 5481
反应条件
sodium nitrite in hydrogenchloride; water; ethyl acetate
参考文献
Inghardt, Tord; Svensson, Arne N.
Patent: US2002/68730 A1, 2002 ;
反应条件
1: 1.) HNO2, 2.) CuCl2, CuCl, 12percent aq. HCl / 1.) 0 deg C, 2.) 60 deg C, 1 h
2: 81 percent / Fe, HCl (gas) / ethanol
3: 65 percent / aq. HBF4, NaNO2 / -5 °C
4: 25 percent / Heating
5: 73 percent / MnO2 / benzene / 24 h / Heating
6: 1 h / 80 °C
7: LiAlH4 / diethyl ether / 2 h / Heating
View Scheme
参考文献
Meindl; Von Angerer; Schonenberger; Ruckdeschel
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1111 - 1118
反应条件
1.1: aq. NaNO2; AcOH / 0 °C
1.2: 67 percent / NaI / 0.25 h
2.1: 91 percent / SnCl2 / ethanol / 2.5 h / 70 °C
3.1: aq. NaNO2; AcOH / 0 °C
3.2: 95 percent / NaN3 / 0.25 h
View Scheme
参考文献
Zhang, Ze; Peng, Zhi Wei; Fan, Kun Zeng
Chinese Chemical Letters, 2011 , vol. 22, # 7 p. 785 - 788
