(3-氯-2-甲基苯基)甲醇合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kraus, James M.; Verlinde, Christophe L. M. J.; Karimi, Mandana; Lepesheva, Galina I.; Gelb, Michael H.; Buckner, Frederick S.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1639 - 1647
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 1 h;
2: With water in tetrahydrofuran
参考文献
Allerghan, Inc.
Patent: US2008/194650 A1, 2008 ;
Location in patent: Page/Page column 22 ;
US 20080194650 A1
反应条件
sodium tetrahydroborate in tetrahydrofuran
T=20°C; 3.5 h;
参考文献
Mitchell, Reginald H.; Lai, Yee-Hing
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2534 - 2540
反应条件
1: 47 percent / various solvent(s) / 48 h / 170 °C
2: 88 percent / diisobutylaluminium hydride / hexane; benzene / 3 h / 20 °C
3: 93 percent / NaBH4 / tetrahydrofuran / 3.5 h / 20 °C
View Scheme
参考文献
Mitchell, Reginald H.; Lai, Yee-Hing
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2534 - 2540
反应条件
1: 88 percent / diisobutylaluminium hydride / hexane; benzene / 3 h / 20 °C
2: 93 percent / NaBH4 / tetrahydrofuran / 3.5 h / 20 °C
View Scheme
参考文献
Mitchell, Reginald H.; Lai, Yee-Hing
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2534 - 2540
反应条件
magnesium; ethylene dibromide
1) in THF under refluxtemp., 2) under cooling, 45 min -> 12 h, refluxtemp.; Yield given. Multistep reaction;
参考文献
Mitchell, Reginald H.; Lai, Yee-Hing
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2534 - 2540
反应条件
pyridine; phosphorus tribromide in benzene
2 h;
参考文献
Mitchell, Reginald H.; Lai, Yee-Hing
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2534 - 2540
反应条件
1: 94 percent / PBr3, Py. / benzene / 2 h
2: 89 percent / methanol / 2.5 h / Heating
3: 1) Mg turnings, 1,2-dibromoethane / 1) in THF, 6-8 h, under reflux, 2) in THF, 1 h, 20 deg C -> 1h, reflux
4: 94 percent / NaBH4 / trifluoroacetic acid / 0.25 h / 0 °C
View Scheme
参考文献
Mitchell, Reginald H.; Lai, Yee-Hing
Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2534 - 2540
