比卡鲁胺合成路线

90356-78-8N-[4-氰基-3-(三氟甲基)苯基]-3-[(4-氟苯基)硫基]-2-羟基-2-甲基丙酰胺→90357-06-5比卡鲁胺

参考文献

SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: WO2007/13094 A2, 2007 ;
Location in patent: Page/Page column 10 ;

90356-78-8N-[4-氰基-3-(三氟甲基)苯基]-3-[(4-氟苯基)硫基]-2-羟基-2-甲基丙酰胺→945419-64-7比卡鲁胺砜+90357-06-5比卡鲁胺

参考文献

WO2004/39769 A1, ;

Page 7-8 ;

371-42-6对氟苯硫酚+90357-51-0N-[4-氰基-3-(三氟甲基)苯基]甲基环氧丙烯酰胺→90357-06-5比卡鲁胺

参考文献

SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: WO2007/13094 A2, 2007 ;
Location in patent: Page/Page column 10 ;

455-15-2对氟苯甲砜+87310-69-8N-[4-氰基-3-(三氟甲基)苯基]-2-氧代丙酰胺→90357-06-5比卡鲁胺

参考文献

Parent, Ephraim E.; Dence, Carmen S.; Jenks, Carl; Sharp, Terry L.; Welch, Michael J.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 5 p. 1028 - 1040

824-80-6对氟苯亚磺酸钠+90357-51-0N-[4-氰基-3-(三氟甲基)苯基]甲基环氧丙烯酰胺→90357-06-5比卡鲁胺

参考文献

Thijs, Lambertus; Keltjens, Rolf; Ettema, Gerrit J. B.
Patent: US2004/68135 A1, 2004 ;
Location in patent: Page 16 ;

937-14-4间氯过氧苯甲酸+90356-78-8N-[4-氰基-3-(三氟甲基)苯基]-3-[(4-氟苯基)硫基]-2-羟基-2-甲基丙酰胺→90357-06-5比卡鲁胺

参考文献

Nobex Corporation
Patent: US6583306 B1, 2003 ;

216665-25-7+824-80-6对氟苯亚磺酸钠→90357-06-5比卡鲁胺

参考文献

Thijs, Lambertus; Keltjens, Rolf; Ettema, Gerrit J. B.
Patent: US2004/68135 A1, 2004 ;
Location in patent: Page 17 ;

→90357-06-5比卡鲁胺

参考文献

EP1189898 B1, ;

1067225-62-0+432-98-4→90357-06-5比卡鲁胺

参考文献

Kalinski, Cedric; Lemoine, Hugues; Schmidt, Juergen; Burdack, Christoph; Kolb, Juergen; Umkehrer, Michael; Ross, Guenther
Synthesis, 2008 , # 24 art. no. T05808SS, p. 4007 - 4011

90357-53-2N-(4-氰基-3-三氟甲基苯基)甲基丙烯酰胺→90357-06-5比卡鲁胺

参考文献

Journal of Organic Chemistry, , vol. 68, # 26 p. 10181 - 10182