(R)-2-羟基-3-甲基丁酸甲酯合成路线

220498-08-8?-2-异丙基琥珀酸甲酯

参考文献

Cregge, Robert J.; Durham, Sherrie L.; Farr, Robert A.; Gallion, Steven L.; Hare, C. Michelle; Hoffman, Robert V.; Janusz, Michael J.; Kim, Hwa-Ok; Koehl, Jack R.; Mehdi, Shujaath; Metz, William A.; Peet, Norton P.; Pelton, John T.; Schreuder, Herman A.; Sunder, Shyam; Tardif, Chantal
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2461 - 2480

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

208113-95-52-异丙基丁二酸

参考文献

Cregge, Robert J.; Durham, Sherrie L.; Farr, Robert A.; Gallion, Steven L.; Hare, C. Michelle; Hoffman, Robert V.; Janusz, Michael J.; Kim, Hwa-Ok; Koehl, Jack R.; Mehdi, Shujaath; Metz, William A.; Peet, Norton P.; Pelton, John T.; Schreuder, Herman A.; Sunder, Shyam; Tardif, Chantal
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2461 - 2480

3952-67-82-氧代-3-甲基丁酸甲酯

24347-63-5(S)-2-羟基-3-甲基丁酸甲酯+

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Mashima, Kazushi; Kusano, Koh-hei; Sato, Naomasa; Matsumura, Yoh-ichi; Nozaki, Kyoko; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3064 - 3076

67-56-1甲醇+

17407-56-6D-α-羟基异戊酸+

18107-18-1三甲基硅烷化重氮甲烷

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Martinborough, Esther; Fanning, Lev T.D.; Sheth, Urvi; Wilson, Dean; Termin, Andreas; Neubert, Timothy; Zimmermann, Nicole; Knoll, Tara; Whitney, Tara; Kawatkar, Arati; Lehsten, Danielle; Stamos, Dean; Zhou, Jinglan; Arumugam, Vijayalaksmi; Gutierrez, Corey
Patent: US2008/27067 A1, 2008 ;
Location in patent: Page/Page column 285 ;

3952-67-82-氧代-3-甲基丁酸甲酯

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Nakamura, Kaoru; Yoneda, Tetsuo; Miyai, Takehiko; Ushio, Kazutoshi; Oka, Shinzaburo; Ohno, Atsuyoshi
Tetrahedron Letters, 1988 , vol. 29, # 20 p. 2453 - 2454

879212-94-9

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Bekele, Tefsit; Shah, Meha H.; Wolfer, Jamison; Abraham, Ciby J.; Weatherwax, Anthony; Lectka, Thomas
Journal of the American Chemical Society, 2006 , vol. 128, # 6 p. 1810 - 1811

108-12-3异戊酰氯

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Bekele, Tefsit; Shah, Meha H.; Wolfer, Jamison; Abraham, Ciby J.; Weatherwax, Anthony; Lectka, Thomas
Journal of the American Chemical Society, 2006 , vol. 128, # 6 p. 1810 - 1811

17407-56-6D-α-羟基异戊酸

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Koch, Patrick; Nakatani, Yoichi; Luu, Bang; Ourisson, Guy
Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 7/8 p. 185 - 194

640-68-6D-缬氨酸

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Hanessian; Ma; Wang
Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10200 - 10206

186581-53-3重氮甲烷+

17407-56-6D-α-羟基异戊酸

90244-32-9(R)-2-羟基-3-甲基丁酸甲酯

参考文献

Pansare, Sunil V.; Ravi, R. Gnana
Tetrahedron, 1998 , vol. 54, # 48 p. 14549 - 14564