3-溴-6-硝基喹啉-4-胺合成路线 （共 5 条）
反应条件
sulfuric acid; nitric acid
T=0°C; 1 h;
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
反应条件
1: 82 percent / Br2; AcOH / 0.5 h / 20 °C
2: 47 percent / HNO3; H2SO4 / 1 h / 0 °C
View Scheme
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
反应条件
1: 79 percent / Fe; AcOH / 3 h / 110 °C
2: 82 percent / Br2; AcOH / 0.5 h / 20 °C
3: 47 percent / HNO3; H2SO4 / 1 h / 0 °C
View Scheme
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
反应条件
sulfuric acid; nitric acid
参考文献
Mizoguchi
Pharmaceutical Bulletin, 1955 , vol. 3, p. 227
反应条件
hydrogenchloride; palladium on activated charcoal
Hydrogenation;
参考文献
Ochiai; Morishita
Yakugaku Zasshi, 1956 , vol. 76, p. 531,533
Chem.Abstr., <1957> 412
