(S)-2-苄基-N,N-二甲基氮丙啶-1-磺酰胺合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Hannam, Joanne; Harrison, Timothy; Heath, Felicity; Madin, Andrew; Merchant, Kevin
Synlett, 2006 , # 6 p. 833 - 836
反应条件
sodium hydride in 2-methyl tetrahydrofuran
T=0 - 20°C;
参考文献
Polniaszek, Richard; Pfeiffer, Steven; Yu, Richard; Cullen, Aaron; Dowdy, Eric; Tran, Duong; Kent, Kenneth; Zhou, Zhongxin; Cordeau, Doug; Easton, Leah
Patent: US2010/256366 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 62 percent / DIAD; PPh3 / toluene / Heating
2: 78 percent / Et3N / CH2Cl2 / 20 °C
View Scheme
参考文献
Hannam, Joanne; Harrison, Timothy; Heath, Felicity; Madin, Andrew; Merchant, Kevin
Synlett, 2006 , # 6 p. 833 - 836
反应条件
1.1: sodium tetrahydroborate / water / 16 h / 0 - 5 °C
1.2: pH 5
1.3: 3 h / |Reflux
2.1: triethylamine / dichloromethane / |Reflux
3.1: tetrabutylammomium bromide; potassium carbonate; p-toluenesulfonyl chloride / dichloromethane / 0 - 25 °C
View Scheme
参考文献
MYLAN LABORATORIES LTD.; RAMA, Shankar; VADALI, Lakshmana Rao; KONDA, Ramesh Babu; JALDU, Ravikanth; VEMAVARAPU, Govardhana Phani Sharma; PALLA, Vijay Kumar; YERVA, Eswara Reddy
Patent: WO2014/57498 A2, 2014 ;
