4-醛基-3-硝基-苯腈合成路线 （共 11 条）
反应条件
triethylamine in dimethyl sulfoxide T=80°C; 2.5 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2003/104227 A1, 2003 ;
Location in patent: Page column 59 ;
反应条件
1.1: bromo-dimethylsulfonium bromide / dichloromethane / 1 h / 20 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: acetic acid; iron / ethanol / 0.08 h / 20 °C / |Reflux 3.1: potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide / 1,4-dioxane / 12 h / |Schlenk technique; |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 55, # 13 p. 2056 - 2060
反应条件
sodium periodate in tetrahydrofuran; water
2.5 h;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Patent: EP1719767 A1, 2006 ;
Location in patent: Page/Page column 24-28; 41 ;
反应条件
1: 99 percent / dimethylformamide / Heating
2: 77 percent / NaIO4 / tetrahydrofuran; H2O / 2.5 h
View Scheme
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
反应条件
hydrogenchloride
0.166667 h; Heating;
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: 96 percent / KOH / 0.25 h / Heating
2: 97 percent / 2 N NaOH / ethanol / 1 h / 5 - 10 °C
3: 63 percent / 18 percent HCl / 0.17 h / Heating
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: 97 percent / 2 N NaOH / ethanol / 1 h / 5 - 10 °C
2: 63 percent / 18 percent HCl / 0.17 h / Heating
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
sodium hydride in tetrahydrofuran
T=0 - 35°C; 3 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1541576 A1, 2005 ;
Location in patent: Page/Page column 42 ;
EP 1541576 A1
反应条件
1: 49 percent / 10 percent sodium methanolate / methanol / 0.5 h / Ambient temperature
2: 78 percent / triethylphosphite / 20 h / Heating
3: 2) 2N HCl / 2) 1 h
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
反应条件
1: 49 percent / 10 percent sodium methanolate / methanol / 0.5 h / Ambient temperature
2: 78 percent / triethylphosphite / 20 h / Heating
View Scheme
参考文献
Dann; Ruff; Wolff; Griessmeier
1984 , vol. 1984, # 3 p. 409 - 425
