1: With diethyl methoxy borane in tetrahydrofuran; methanol T=-78 - -75°C; 0.833333 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=-78°C; 2 h; 3: With acetic acid in tetrahydrofuran; methanol

1: trans-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide With lithium chloride; (S)-(-)-1,1'-bi-(2-naphthyloxy)(diisopropoxy)titanium in tetrahydrofuran T=20°C; 0.166667 h; 2: 1-ethoxy-1,3-bis-(trimethylsilanyloxy)-buta-1,3-diene With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=20°C; 3: With phosphoric acid; trifluoroacetic acid more than 3 stages;

hydrogenchloride; water in tetrahydrofuran T=0 - 25°C; 1.5 h;

1: trans-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide With lithium chloride; (S)-(-)-1,1'-bi-(2-naphthyloxy)(diisopropoxy)titanium in tetrahydrofuran T=18 - 25°C; 0.0833333 h; 2: Brassard's diene in tetrahydrofuran T=0 - 25°C; 42.17 h; 3: With hydrogenchloride in tetrahydrofuran; water T=0°C; Product distribution / selectivity;

1: With hydrogen fluoride in water; acetonitrile T=0 - 30°C; 0.333333 - 2.25 h; 2: With sodium hydrogencarbonate in water; acetonitrile Product distribution / selectivity;