4-羟基-2-甲氧基苯甲酸合成路线 （共 11 条）
反应条件
in diethyl ether Ambient temperature;
参考文献
Chopra, Neeraj; Alam, M. Sarwar; Ali
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 12 p. 1352 - 1353
反应条件
sodium hydroxide in methanol
参考文献
Kuo, Michelle S.; Bock, Mark G.; Freidinger, Roger M.; Guidotti, Maribeth T.; Lis, Edward V.; Pawluczyk, Joseph M.; Perlow, Debra S.; Pettibone, Douglas J.; Quigley, Amy G.; Reiss, Duane R.; Williams, Peter D.; Woyden, Carla J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3081 - 3086
反应条件
hydrogen; 30 Pd/C in methanol
T=20°C; P=3102.97 Torr; 24 h;
参考文献
Barber, Christopher Gordon; Bunnage, Mark Edward; Harvey, John Wilson; Mathias, John Paul
Patent: US2005/20611 A1, 2005 ;
Location in patent: Page/Page column 40 ;
反应条件
1: 58 percent / K2CO3 / acetone
2: 96 percent / NaH / dimethylformamide
3: 86 percent / H2, AcOH / Pd/C / methanol
4: 95 percent / aq. NaOH / methanol
View Scheme
参考文献
Kuo, Michelle S.; Bock, Mark G.; Freidinger, Roger M.; Guidotti, Maribeth T.; Lis, Edward V.; Pawluczyk, Joseph M.; Perlow, Debra S.; Pettibone, Douglas J.; Quigley, Amy G.; Reiss, Duane R.; Williams, Peter D.; Woyden, Carla J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3081 - 3086
反应条件
1: 86 percent / H2, AcOH / Pd/C / methanol
2: 95 percent / aq. NaOH / methanol
View Scheme
参考文献
Kuo, Michelle S.; Bock, Mark G.; Freidinger, Roger M.; Guidotti, Maribeth T.; Lis, Edward V.; Pawluczyk, Joseph M.; Perlow, Debra S.; Pettibone, Douglas J.; Quigley, Amy G.; Reiss, Duane R.; Williams, Peter D.; Woyden, Carla J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3081 - 3086
反应条件
1: 96 percent / NaH / dimethylformamide
2: 86 percent / H2, AcOH / Pd/C / methanol
3: 95 percent / aq. NaOH / methanol
View Scheme
参考文献
Kuo, Michelle S.; Bock, Mark G.; Freidinger, Roger M.; Guidotti, Maribeth T.; Lis, Edward V.; Pawluczyk, Joseph M.; Perlow, Debra S.; Pettibone, Douglas J.; Quigley, Amy G.; Reiss, Duane R.; Williams, Peter D.; Woyden, Carla J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3081 - 3086
反应条件
sodium hydroxide
T=25°C;
参考文献
Fischer,E.; Pfeffer
Justus Liebigs Annalen der Chemie, 1912 , vol. 389, p. 211
反应条件
1: ZnCl2; HCl; diethyl ether
2: aqueous NaHCO3
View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1951 , p. 665,669
反应条件
potassium permanganate; water
man spaltet aus der Methoxy-acetoxy-benzoesaeure die Acetylgruppe durch Kochen mit Kalilauge ab;
参考文献
Tiemann; Parrisius
Chemische Berichte, 1880 , vol. 13, p. 2366
反应条件
1: KOH; methanol / Verdampfen zur Trockne und lassen den Rueckstand 6-8 Stdn. mit einer Loesung von 1.4 Tln. Essigsaeureanhydrid in wasserfreim Aether stehen
2: water; KMnO4 / man spaltet aus der Methoxy-acetoxy-benzoesaeure die Acetylgruppe durch Kochen mit Kalilauge ab
View Scheme
参考文献
Tiemann; Parrisius
Chemische Berichte, 1880 , vol. 13, p. 2366
