(S)-1-boc-2,3-二氢-1H-吡咯-2-羧酸合成路线 （共 4 条）
反应条件
lithium hydroxide in methanol; water
T=20°C; 3 h;
参考文献
Woo, Grace H.C.; Kim, Se-Ho; Wipf, Peter
Tetrahedron, 2006 , vol. 62, # 45 p. 10507 - 10517
反应条件
2-(2-dimethylaminoethoxy)ethanol, sodium salt in toluene; acetonitrile
T=20°C; 20 h;
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: Et3N / CH2Cl2 / 1 h / 0 °C
2: 85.5 kg / Et3N / CH2Cl2 / 0 °C
3: NaOC2H4OC2H4NMe2 / acetonitrile; toluene / 20 h / 20 °C
View Scheme
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: With sodium hydroxide; water
T=40°C; 2 h;
2: With hydrogenchloride in water
T=5°C; pH=5;
3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite
Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: WO2006/80401 A1, 2006 ;
Location in patent: Page/Page column 38-40 ;
