N-(4-甲基-2-吡啶基)-氨基甲酸-1,1-二甲基乙酯合成路线 （共 37 条）
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.5 h;
2: 2-methyl-1-[3-(trifluoromethyl)benzoyl]aziridine in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.5 h;
2: 1-(3-chlorobenzoyl)-2-methylaziridine in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.2: 78 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 64 percent / Br2; AcOH / 3 h / 80 °C
3.1: 81 percent / dimethylformamide / 14 h / 20 °C
View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.2: 72 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 86 percent / Br2; AcOH / 3 h / 80 °C
3.1: 84 percent / dimethylformamide / 14 h / 20 °C
View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.2: 70 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 93 percent / Br2; AcOH / 3 h / 80 °C
3.1: 72 percent / dimethylformamide / 14 h / 20 °C
View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 0.5 h;
2: 4-fluoro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=-78 - 20°C; 2 h;
3: With water in tetrahydrofuran; hexane
T=20°C;
参考文献
DONGBU HANNONG CHEMICALS CO., LTD.
Patent: WO2006/137658 A1, 2006 ;
Location in patent: Page/Page column 124-125 ;
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.5 h;
2: 1-(4-fluorobenzoyl)-2-methylaziridine in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
