N-(4-甲基-2-吡啶基)-氨基甲酸-1,1-二甲基乙酯合成路线 （共 37 条）
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C 4.1: 75 percent / Et3N / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 71 percent / dimethylformamide / 14 h / 20 °C 4.1: 77 percent / Et3N / tetrahydrofuran / 1 h / 20 °C 5.1: 35 percent / LiAlH4; AlCl3 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: 1-(3-methylbenzoyl)-2-methylaziridine in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1364949 A1, 2003 ;
Location in patent: Page/Page column 80 ;
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium 2: N-(3-methylbenzoyl)propyleneimine
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1180518 A1, 2002 ;
Location in patent: Referential example 14 ;
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 63 percent / dimethylformamide / 14 h / 20 °C 4.1: 95 percent / NaOH / ethanol; H2O / 2 h / 20 °C 5.1: 72 percent / 0.25 h / 140 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 71 percent / dimethylformamide / 14 h / 20 °C 4.1: Et3N / tetrahydrofuran / 3 h / 20 °C 5.1: HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
n-butyllithium in tetrahydrofuran; hexane; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1402900 A1, 2004 ;
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: (4-methoxyphenyl)(2-methylaziridin-1-yl)methanone in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=20°C; 0.5 h; 2: N-(4-methoxybenzoyl)propyleneimine T=20°C; 2 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1180518 A1, 2002 ;
Location in patent: Referential example 6 ;
