N-(4-甲基-2-吡啶基)-氨基甲酸-1,1-二甲基乙酯合成路线 （共 37 条）
反应条件
in tert-butyl alcohol
参考文献
Ihle; Krause
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4810 - 4811
反应条件
di-tert-butyl dicarbonate in tert-butyl alcohol T=23°C;
参考文献
SCHERING CORPORATION
Patent: WO2003/103669 A1, 2003 ;
Location in patent: Page 20 ;
WO 03/103669 A1
反应条件
zinc(II) chloride in dichloromethane T=20°C; 0.333333 h;
参考文献
Arifuddin, M.; Lakshmikant, N.; Rajasekar, N.; Shinde, D. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012 , vol. 51, # 8 p. 1168 - 1172,5
反应条件
in tert-butyl alcohol
参考文献
US2009/270462 A1, ;
US 20090270462 A1
反应条件
in tert-butyl alcohol T=30°C;
参考文献
Pharmacia Corporation
Patent: US6664255 B1, 2003 ;
Location in patent: Page column 104; 105 ;
US 6664255 B1
反应条件
n-butyllithium in tetrahydrofuran; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5852045 A1, 1998 ;
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 62 percent / dimethylformamide / 14 h / 20 °C 4.1: Et3N / tetrahydrofuran / 3 h / 20 °C 5.1: HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C 4.1: 88 percent / Et3N / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 71 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 62 percent / dimethylformamide / 14 h / 20 °C View Scheme
参考文献
Miwatashi, Seiji; Arikawa, Yasuyoshi; Kotani, Etsuo; Miyamoto, Maki; Naruo, Ken-Ichi; Kimura, Hiroyuki; Tanaka, Toshimasa; Asahi, Satoru; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5966 - 5979
