in ethanol; acetone T=20°C; 18 h; Resolution of racemate; Purification / work up;

1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / methanol; water / 0.5 h / |Reflux 1.2: 12 h / 40 °C 2.1: L-CSA*1H2O / toluene / 49 h / 20 - 50 °C / |Resolution of racemate 2.2: 6 h / |Resolution of racemate; |Reflux View Scheme

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / methanol; water / 0.5 h / 10 - 40 °C / |Reflux; |Green chemistry 1.2: 12 h / 40 °C / |Green chemistry 2.1: (-)-10-CSA / water; toluene / 49 h / 20 - 50 °C / |Green chemistry 3.1: sulfuric acid / 12 h / 0 °C / |Green chemistry View Scheme

1: clopidigrel acid With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in methanol; water 0.5 h; Reflux; 2: dimethyl sulfate in methanol; water T=40°C; 12 h;

sulfuric acid in water 72 h; Reflux;