2-羟基-4,6-二甲氧基苯乙酮合成路线 （共 113 条）
反应条件
1: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 2: 99 percent / K2CO3 / acetone / Heating 3: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 4: 59 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Kavvadias, Dominique; Sand, Philipp; Youdim, Kuresh A.; Qaiser, M. Zeeshan; Rice-Evans, Catherine; Baur, Roland; Sigel, Erwin; Rausch, Wolf-Dieter; Riederer, Peter; Schreier, Peter
British Journal of Pharmacology, 2004 , vol. 142, # 5 p. 811 - 820
反应条件
1: 90 percent / KOH / methanol / 24 h / 20 °C 2: 84 percent / pyridine / methanol; H2O / 12 h / Heating 3: 92 percent / thallium(III) p-tosylate / acetonitrile / 2 h / Heating View Scheme
参考文献
Singh, Om V.; Muthukrishnan; Sunderavadivelu
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 12 p. 2575 - 2581
反应条件
1: 1.) Lithium diisopropylamide / THF 2: 87 percent / conc. H2SO4 / acetic acid View Scheme
参考文献
Zhang, Ji; Liu, Man; Cui, Wei; Yang, Jian; Yang, Bo
Journal of Chemical Research, 2014 , vol. 38, # 1 p. 60 - 61
反应条件
potassium carbonate; toluene-4-sulfonic acid; tetra(n-butyl)ammonium hydrogensulfate 1.) benzene, 80 deg C, 3 h, 2.) benzene, reflux, 45 min; Yield given. Multistep reaction;
参考文献
Jain, P. K.; Makrandi, J. K.; Grover, S. K.
Synthesis, 1982 , # 3 p. 221 - 222
反应条件
1: piperonal; methanol; aq. NaOH solution 2: aq.-ethanolic hydrochloric acid 3: ethanol; pentyl nitrite; aqueous hydrochloric acid 4: acetic acid; aqueous sulfuric acid / 120 °C 5: AlCl3; chlorobenzene / 130 °C / Erwaermen des Reaktionsgemisches mit wss. HCl View Scheme
参考文献
Ozawa et al.
Yakugaku Zasshi, 1951 , vol. 71, p. 1178,1182
Chem.Abstr., 1952 , p. 6124
反应条件
sodium hydroxide in acetone 24 h; Reflux;
参考文献
Bello, Murilo Lamim; Chiaradia, Louise Domeneghini; Dias, Luiza Rosaria Sousa; Pacheco, Leticia Kramer; Stumpf, Taisa Regina; Mascarello, Alessandra; Steindel, Mario; Yunes, Rosendo Augusto; Castro, Helena Carla; Nunes, Ricardo Jose; Rodrigues, Carlos Rangel
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 5046 - 5052
参考文献
Ghosal, Shibnath; Mittal, Peeyush; Kumar, Yatendra; Singh, Sushil, K.
Phytochemistry (Elsevier), 1989 , vol. 28, # 11 p. 3193 - 3196
反应条件
1: in pyridine T=70 - 75°C; Baker-Venkataraman synthesis; 12 h; Heating; 2: With potassium hydroxide in pyridine T=60 - 70°C; 5 h; 3: With sulfuric acid in acetic acid T=60 - 70°C; 5 h; Heating;
参考文献
Mateeva, Nelly N.; Kode, Rao N.; Redda, Kinfe K.
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1251 - 1258
反应条件
1: 1.27 g / pyridine 2: KOH / pyridine / 48 h / Ambient temperature View Scheme
参考文献
Imai, Fujio; Itoh, Kikuo; Kishibuchi, Noriko; Kinoshita, Takeshi; Sankawa, Ushio
Chemical & Pharmaceutical Bulletin, 1989 , vol. 37, # 1 p. 119 - 123
反应条件
lithium diphenylphosphinide in tetrahydrofuran; hexane T=50°C; 1 h;
参考文献
Bringmann, Gerhard; Menche, Dirk; Brun, Reto; Msuta, Thomas; Abegaz, Berhanu
European Journal of Organic Chemistry, 2002 , # 6 p. 1107 - 1111
