5-甲基-苯并[d]异噁唑-3-胺合成路线 (共 2 条)
反应条件
1: methanecarbohydroxamic acid With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: 2-fluoro-5-methylbenzonitrile in N,N-dimethyl-formamide T=20°C; 72 h;
参考文献
DAIAMED, INC.
Patent: WO2006/108039 A2, 2006 ;
Location in patent: Page/Page column 120 ;
WO 2006/108039 A2
反应条件
1: acetone-oxime With potassium tert-butylate in tetrahydrofuran T=20°C; 0.333333 h; 2: 2-fluoro-5-methylbenzonitrile in tetrahydrofuran T=20 - 60°C; 3: With hydrogenchloride; sodium hydroxide; sodium carbonate more than 3 stages;
参考文献
US2007/225282 A1, ;
Page/Page column 25 ;
US 20070225282 A1