2-甲基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 20 条）
反应条件
water in methanol T=30 - 50°C; ΔH(excit), ΔS(excit), log A; Rate constantThermodynamic dataKinetics;
参考文献
Crombie, Aimee L.; Antrilli, Thomas M.; Campbell, Brandon A.; Crandall, David L.; Failli, Amedeo A.; He, Yanan; Kern, Jeffrey C.; Moore, William J.; Nogle, Lisa M.; Trybulski, Eugene J.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3742 - 3745
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Merck and Co., Inc.
Patent: US5102880 A1, 1992 ;
US 5102880 A
反应条件
tetrachloromethane; N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile T=95°C;
参考文献
Dodo, Kosuke; Aoyama, Atsushi; Noguchi-Yachide, Tomomi; Makishima, Makoto; Miyachi, Hiroyuki; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4272 - 4285
反应条件
cesium fluoride; [Me2NCH2(Cl)C=C(CH2)2OP(i-Pr)2-κNκCκP]PdCl in 1,4-dioxane
T=130°C; Suzuki reaction; 27 h;
参考文献
Rosa, Gilber R.; Ebeling, Gunter; Dupont, Jairton; Monteiro, Adriano L.
Synthesis, 2003 , # 18 p. 2894 - 2897
反应条件
1: 2-methylphenylmagnesium chloride With zinc(II) chloride in tetrahydrofuran
T=20°C; 0.333333 h;
2: 4-chlorobenzoic acid methyl ester With Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi reaction; 2 h; Further stages.;
参考文献
Dai; Fu
Journal of the American Chemical Society, 2001 , vol. 123, # 12 p. 2719 - 2724
反应条件
KF in tetrahydrofuran
参考文献
Yale University
Patent: US6562989 B2, 2003 ;
反应条件
potassium phosphate; C58H72N2O4P2Pd2 in tert-butyl alcohol
T=110°C; Suzuki-Miyaura cross-coupling; 3 h; Inert atmosphere;
参考文献
So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Angewandte Chemie - International Edition, 2008 , vol. 47, # 42 p. 8059 - 8063
反应条件
potassium phosphate; Ni(PCy3)2Cl2; water; tri-cyclo-hexyl-phosphine in 1,4-dioxane
T=110°C; 12 h; Inert atmosphere;
参考文献
Guan, Bing-Tao; Wang, Yang; Li, Bi-Jie; Yu, Da-Gang; Shi, Zhang-Jie
Journal of the American Chemical Society, 2008 , vol. 130, # 44 p. 14468 - 14470
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=100°C; Suzuki coupling;
参考文献
Dodo, Kosuke; Aoyama, Atsushi; Noguchi-Yachide, Tomomi; Makishima, Makoto; Miyachi, Hiroyuki; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4272 - 4285
反应条件
potassium phosphate; tri(2-methoxy-phenyl)-phosphine; polymer-incarcerated palladium in water; toluene
Suzuki-Miyaura coupling; 2 h; Heating;
参考文献
Okamoto, Kuniaki; Akiyama, Ryo; Kobayashi, Shu
Organic Letters, 2004 , vol. 6, # 12 p. 1987 - 1990
