2-溴-4-(溴甲基)苯腈合成路线 （共 6 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
4 h; Reflux;
参考文献
Glaxo Group Limited
Patent: US2009/197871 A1, 2009 ;
Location in patent: Page/Page column 48 ;
US 20090197871 A1
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 50 °C
2: ammonia / toluene; water
3: phosphorous pentoxide / chloroform / 12 h / Reflux
4: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 4 h / Reflux
View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1: phosphorous pentoxide / chloroform / 12 h / Reflux
2: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 4 h / Reflux
View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1: ammonia / toluene; water
2: phosphorous pentoxide / chloroform / 12 h / Reflux
3: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 4 h / Reflux
View Scheme
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
WO 2009/100169 A1
反应条件
1: H2O
2: HNO3
View Scheme
参考文献
Hazlet,S.E. et al.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2034 - 2036
参考文献
Hazlet,S.E. et al.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2034 - 2036
