2,3-二氯-5-(5-乙基-1,3-噁唑-2-基)-4-(甲基硫代)吡啶合成路线 (共 1 条)
反应条件
1: 2,3-dichloro-5-(5-ethyl-1,3-oxazol-2-yl)pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78 - 0°C; 1.5 h;
2: methanethiosulfonic acid S-methyl ester in tetrahydrofuran
T=-78 - 20°C; 16 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73361 A1, 2006 ;
Location in patent: Page/Page column 185 ;
WO 2006/073361 A1