2-氟-4-(三氟甲基)苯甲醛合成路线 （共 7 条）
反应条件
in hexane; dichloromethane; ethyl acetate
参考文献
US2003/195201 A1, ;
US 20030195201 A1
反应条件
fluorine in acetonitrile T=0°C; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 12, # 2 p. 339 - 344
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 140 °C 2: water; lithium hydroxide hydrate / methanol / 2 h / 75 °C View Scheme
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; MUKUMOTO, Fujio; TAMAKI, Hiroaki; IWAKOSHI, Mitsuhiko; KUSAKA, Shintaro
Patent: WO2012/153861 A1, 2012 ;
反应条件
methanol T=50°C; 6 h;
参考文献
WO2009/158426 A1, ;
Page/Page column 69 ;
WO 2009/158426 A1
反应条件
sodium tetrahydroborate in ethanol T=0 - 20°C; 1 h;
参考文献
Stazi, Federica; Maton, William; Castoldi, Damiano; Westerduin, Pieter; Curcuruto, Ornella; Bacchi, Sergio
Synthesis, 2010 , # 19 art. no. T09110SS, p. 3332 - 3338
反应条件
sodium cyanoborohydride; acetic acid in methanol
T=20°C; 72 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/8156 A1, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/008156 A1
反应条件
sodium cyanoborohydride; acetic acid; N-butylamine in methanol; n-heptane; water; ethyl acetate
参考文献
Alstermark, Eva-Lotte Lindstedt; Olsson, Anna Christina; Li, Lanna
Patent: US2005/282822 A1, 2005 ;
