N-Boc-2-氨基乙醛合成路线 （共 17 条）
反应条件
1: 1.) DIEA, BOP, 2.) DIEA / 1.) r.t., 5 min, 2.) CH2Cl2, r.t., 4.5 h 2: 36 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 10 p. 1501 - 1510
反应条件
1: NaBH4 / H2O / 0 °C 2: 62 percent / pyridine-SO3; NEt3; DMSO / CH2Cl2 / -10 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-toluenesulfonyl azide; potassium carbonate in acetonitrile T=0°C; 1 h; Inert atmosphere; 2: N-tert-butoxycarbonylglycinal in methanol; acetonitrile T=0 - 20°C;
参考文献
Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264
反应条件
1: diethyl carboxymethylphosphonate With n-butyllithium in tetrahydrofuran T=-60°C; 0.5 h; 2: N-tert-butoxycarbonylglycinal in tetrahydrofuran T=-60 - 25°C; Horner olefination; 4 h;
参考文献
Grison, Claude; Geneve, Stephane; Halbin, Etienne; Coutrot, Philippe
Tetrahedron, 2001 , vol. 57, # 23 p. 4903 - 4923
反应条件
1: in diethyl ether T=20°C; 1.5 h; 2: With acetyl chloride in diethyl ether T=20°C; 0.333333 h;
参考文献
Kelly, T. Ross; Lebedev, Rimma L.
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2197 - 2205
反应条件
1: in tetrahydrofuran; diethyl ether T=0°C; 1 h; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran; diethyl ether
参考文献
Julian, Lisa D.; Hartwig, John F.
Journal of the American Chemical Society, 2010 , vol. 132, # 39 p. 13813 - 13822
反应条件
ammonium chloride; zinc in tetrahydrofuran T=20°C;
参考文献
Zhang, Zuhui; Zhang, Jintang; Tan, Jiajing; Wang, Zhiyong
Journal of Organic Chemistry, 2008 , vol. 73, # 13 p. 5180 - 5182
