5-氯-2-甲氧基苯硼酸合成路线 （共 15 条）
反应条件
n-butyllithium in 5-fluoro-2-methoxyphenyl-boronic acid
参考文献
US5688808 A1, ;
US 5688808 A
反应条件
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione; sodium methylate in methanol; water; acetonitrile T=60°C;
参考文献
Journal of Organic Chemistry, , vol. 69, # 2 p. 566 - 569
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; ice-water
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With triisopropyl borate 3: With hydrogenchloride in water; ethyl acetate
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 17 p. 6626 - 6637
反应条件
chlorine in acetic acid
参考文献
Tetrahedron, , vol. 19, p. 821 - 826
反应条件
1: With sodium hydroxide; water T=20°C; 0.333333 h; 2: With Oxonereg;; ethylenediaminetetraacetic acid; sodium hydrogencarbonate in acetone T=0 - 20°C; 24 h; 3: With hydrogenchloride; sodium sulfite in ethyl acetate; acetone
参考文献
PFIZER LIMITED
Patent: WO2006/67587 A2, 2006 ;
Location in patent: Page/Page column 22; 23 ;
反应条件
boron tribromide in dichloromethane T=0°C; 0.25 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 37 p. 9755 - 9758
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; 2 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 14, # 13 p. 3454 - 3457
反应条件
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 80 °C 2: tert-butyl alcohol; sodium dihydrogenphosphate; potassium permanganate / water / 2 h / 20 °C View Scheme
参考文献
Journal of Natural Products, , vol. 76, # 12 p. 2234 - 2245
