4-氨基-3-磺酰基-苯甲酸合成路线 （共 8 条）
反应条件
sulfuric acid
Heating;
参考文献
Boverie, Stephane; Antoine, Marie-Helene; Somers, Fabian; Becker, Benedicte; Sebille, Sophie; Ouedraogo, Raogo; Counerotte, Stephane; Pirotte, Bernard; Lebrun, Philippe; De Tullio, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3492 - 3503
反应条件
ammonium hydroxide; (NH4)2CO3; copper(II) sulfate
T=130°C; 18 h;
参考文献
Bierbaum,B.A. et al.
J. Med. Chem., 1963 , vol. 6, p. 272 - 275
反应条件
1.1: nitromethane / -5 °C
1.2: 55 percent / AlCl3 / nitromethane / 0.5 h / Heating
2.1: 66 percent / aq. NaOH; KMnO4 / 3 h / 70 °C
3.1: 91 percent / aq. sulfuric acid / Heating
View Scheme
参考文献
Boverie, Stephane; Antoine, Marie-Helene; Somers, Fabian; Becker, Benedicte; Sebille, Sophie; Ouedraogo, Raogo; Counerotte, Stephane; Pirotte, Bernard; Lebrun, Philippe; De Tullio, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3492 - 3503
反应条件
1: 66 percent / aq. NaOH; KMnO4 / 3 h / 70 °C
2: 91 percent / aq. sulfuric acid / Heating
View Scheme
参考文献
Boverie, Stephane; Antoine, Marie-Helene; Somers, Fabian; Becker, Benedicte; Sebille, Sophie; Ouedraogo, Raogo; Counerotte, Stephane; Pirotte, Bernard; Lebrun, Philippe; De Tullio, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3492 - 3503
反应条件
1: (i) ClSO3H, NaCl, (ii) liq. NH3
2: aq. NH3, (NH4)2CO3, CuSO4 / 18 h / 130 °C
View Scheme
参考文献
Bierbaum,B.A. et al.
J. Med. Chem., 1963 , vol. 6, p. 272 - 275
反应条件
potassium permanganate; sulfuric acid
参考文献
Szabo
Bulletin de la Societe Chimique de France, 1953 , p. 771,773
反应条件
1: PCl3; PCl5
2: NH3
3: KMnO4; aqueous H2SO4
View Scheme
参考文献
Szabo
Bulletin de la Societe Chimique de France, 1953 , p. 771,773
反应条件
1: NH3
2: KMnO4; aqueous H2SO4
View Scheme
参考文献
Szabo
Bulletin de la Societe Chimique de France, 1953 , p. 771,773
