2-乙酰基氨基-2-吡啶-4-甲基-丙二酸二乙酯合成路线 (共 9 条)
反应条件
1: 100 percent / aq. KOH / ethanol / 1 h / Ambient temperature 2: 67 percent / dimethylformamide / 1.5 h / Heating 3: 100 percent / H2, aq. HCl / 10 percent Pd/C / ethanol 4: 100 percent / 6 N HCl / 4 h / Heating 5: CuSO4, pH 9 / dioxane; H2O / 16 h / Ambient temperature 6: pH 12.5 / 20 h / Ambient temperature View Scheme
参考文献
Adang, Anton E. P.; Peters, Co A. M.; Gerritsma, Siene; De Zwart, Edwin; Veeneman, Gerrit
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1227 - 1232
反应条件
1: 83 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 2: 88 percent / Et3N / acetonitrile / 20 h / Heating 3: 85 percent / 18percent HCl / H2O / 1 h / Heating View Scheme
参考文献
Hilpert, Hans
Helvetica Chimica Acta, 1987 , vol. 70, p. 1307 - 1311
参考文献
Bixler; Niemann
Journal of Organic Chemistry, 1958 , vol. 23, p. 575,580
Full Text Show Details
Niemann et al.
Journal of the American Chemical Society, 1942 , vol. 64, p. 1678,1680
Full Text Show Details
Zymalkowski
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 436,441
反应条件
sodium hydroxide in ethanol; water
参考文献
Bacque, Eric; Bigot, Antony; Carry, Jean-Christophe; Mignani, Serge; Ronan, Baptiste; Tabart, Michel
Patent: US2003/153605 A1, 2003 ;
反应条件
potassium hexamethylsilazane in acetonitrile
T=-40 - 20°C;
参考文献
Moussa, Amer; Meffre, Patrick; Martinez, Jean; Rolland, Valerie
Amino Acids, 2012 , vol. 42, # 4 p. 1339 - 1348
参考文献
Athena Neurosciences, Inc.; American Home Products Corp.
Patent: US6423688 B1, 2002 ;
参考文献
Bixler; Niemann
Journal of Organic Chemistry, 1958 , vol. 23, p. 575,580
Full Text Show Details
Zymalkowski
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 436,441
参考文献
Bixler; Niemann
Journal of Organic Chemistry, 1958 , vol. 23, p. 575,580
Full Text Show Details
Zymalkowski
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 436,441
参考文献
Adang, Anton E. P.; Peters, Co A. M.; Gerritsma, Siene; De Zwart, Edwin; Veeneman, Gerrit
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1227 - 1232