5,6,7,8-四氢-2-氯甲基-(1)苯并噻吩(2,3-d)嘧啶-4(1H)-酮合成路线 （共 6 条）
反应条件
1: toluene / 7.5 h / Heating 2: 10percent aq. Na2CO3 / methanol / overnight 3: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Shishoo; Devani; Ullas; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 825 - 830
反应条件
hydrogenchloride in 1,4-dioxane
6 h; Cooling;
参考文献
Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185
反应条件
polyphosphate ester
8 h; Heating;
参考文献
Kanwar, Seema; Sharma
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371
反应条件
1: 80 percent / sulfur; diethyl amine / 20 - 58 °C
2: 71 percent / pyridine / benzene
3: 82 percent / polyphosphate ester / 8 h / Heating
View Scheme
参考文献
Kanwar, Seema; Sharma
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371
反应条件
1: 71 percent / pyridine / benzene
2: 82 percent / polyphosphate ester / 8 h / Heating
View Scheme
参考文献
Kanwar, Seema; Sharma
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371
反应条件
trichlorophosphate
12 h; Heating;
参考文献
Shishoo, C. J.; Devani, M. B.; Bhadti, V. S; Jain, K. S.; Ananthan, S.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 119 - 126
