4-(4-氟苯基)-5-羟基甲基-6-异丙基-2-甲硫基嘧啶合成路线 （共 5 条）
反应条件
1: With diisobutylaluminium hydride in toluene T=20°C; 2 - 3 h; Cooling with ice/salt; 2: With water in toluene
参考文献
Yao, Hui; Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP1845092 A1, 2007 ;
Location in patent: Page/Page column 14; 16 ;
反应条件
diisobutylaluminium hydride in toluene T=-74°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 2 p. 437 - 444
反应条件
1: 86.7 percent / piperidine, AcOH / benzene / Heating 2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min 3: DIBAL-H / toluene / 1 h / -74 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 2 p. 437 - 444
反应条件
1: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min 2: DIBAL-H / toluene / 1 h / -74 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 2 p. 437 - 444
反应条件
hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; Aliquatreg; 336 in dichloromethane T=20°C; 4 h; Product distribution / selectivity;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/30758 A1, 2005 ;
Location in patent: Page/Page column 59-60 ;
WO 2005/030758 A1
