in dimethyl sulfoxide T=120°C; 24 h;

1: 2-bromo-4-hydroxypyridine With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 72 h;

copper acetylacetonate; potassium phosphate; ammonia in N,N-dimethyl-formamide T=90°C; 24 h; GloveboxAutoclave; chemoselective reaction;