1: 85 percent / hydrogen chloride / benzene / 3 h / Ambient temperature 2: 85 percent / 3N aq. natrium hydroxide / 0.5 h / Heating 3: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C then RT 4: KOtBu / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: 85 percent / 3N aq. natrium hydroxide / 0.5 h / Heating 2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C then RT 3: KOtBu / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C then RT 2: KOtBu / tetrahydrofuran / 1 h / Ambient temperature View Scheme

potassium tert-butylate; lithium diisopropyl amide 1.)-78 deg C,in THF, diluted with ether, 2.) in THF, 1h, at room temperature; Multistep reaction. Title compound not separated from byproducts;