5-氯-2,3-二氟吡啶合成路线 （共 31 条）
反应条件
ammonium formate; acetic acid; palladium on activated charcoal T=25°C; 6 h;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: 91 percent / aq. sodium hydroxide / 20 h / 75 °C 2.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C 3.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 3.2: 71 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
hydrazine hydrate in ethanol 20 h; Heating;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: 87 percent / hydrazine monohydrate / ethanol / 20 h / Heating 2.1: 72 percent / aq. CuSO4 / Heating 3.1: BuLi / tetrahydrofuran; hexane 3.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane 4.1: 71 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 125 °C 5.1: HCOONH4 / Pd/C / octan-1-ol / 6 h / 45 °C 6.1: BuLi; i-Pr2NH / tetrahydrofuran; hexane / 2 h / -75 °C 6.2: 68 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane / 1 h View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
ammonia in water T=150°C; 1 h; Microwave irradiation; Product distribution / selectivity;
参考文献
US2008/242695 A1, ;
Page/Page column 34 ;
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine; potassium acetate / 1,4-dioxane / 16 h / 85 °C / |Inert atmosphere 2: dihydrogen peroxide / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Glaxo Group Limited; Wan, Zehong; Long, Kai; Sang, Yingxia; Su, Xiaobo
Patent: US2014/179715 A1, 2014 ;
反应条件
1.1: 87 percent / hydrazine monohydrate / ethanol / 20 h / Heating
2.1: 72 percent / aq. CuSO4 / Heating
3.1: BuLi / tetrahydrofuran; hexane
3.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane
4.1: 71 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 125 °C
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: 87 percent / hydrazine monohydrate / ethanol / 20 h / Heating
2.1: 72 percent / aq. CuSO4 / Heating
3.1: BuLi / tetrahydrofuran; hexane
3.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
iodine; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-75°C;
参考文献
Bobbio, Carla; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 23 p. 4533 - 4536
反应条件
1.1: sodium hydroxide / water / 2.5 h / Reflux
1.2: 0 °C
2.1: phosphorus oxytribromide / toluene / 4 h / 60 - 110 °C
2.2: 0 °C
3.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C
3.2: -78 - 20 °C
4.1: thionyl chloride / 2 h / Reflux
View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
