5-氯-2,3-二氟吡啶合成路线 （共 31 条）
反应条件
potassium-fluoride in sulfolane; tetrahydrothiophene 1,1-dioxide (sulfolane)
参考文献
Ciba Geigy Corporation
Patent: US4713109 A1, 1987 ;
反应条件
1: 36.1 percent / KF; CsF; K2CO3 / [Bmim]BF4 / 10 h / 200 °C 2: 68.8 percent / CsF; K2CO3; [Bmim]BF4 / 8 h / 100 - 110 °C / 200 Torr View Scheme
参考文献
Synthetic Communications, , vol. 34, # 23 p. 4301 - 4311
反应条件
potassium fluoride; 18-crown-6 ether; cesium fluoride in sulfolane
参考文献
Differding, E.; Frick, W.; Lang, R. W.; Martin, P.; Schmit, C.; et al.
Bulletin des Societes Chimiques Belges, 1990 , vol. 99, # 9 p. 647 - 671
反应条件
potassium fluoride; hydrogen fluoride; tetrabutylammomium bromide; sodium nitrite in sulfolane; dichloromethane
反应条件
[bmim]BF4; potassium carbonate; cesium fluoride T=100 - 110°C; P=200 Torr; 8 h;
参考文献
Zhong, Ping; Hu, Huanan; Guo, Shengrong
Synthetic Communications, 2004 , vol. 34, # 23 p. 4301 - 4311
反应条件
potassium fluoride; potassium carbonate; cesium fluoride in sulfolane
反应条件
potassium fluoride; potassium carbonate; cesium fluoride; [bmim]BF4 T=200°C; 10 h;
参考文献
Synthetic Communications, , vol. 34, # 23 p. 4301 - 4311
反应条件
1: HCl 2: 36.1 percent / KF; CsF; K2CO3 / [Bmim]BF4 / 10 h / 200 °C 3: 68.8 percent / CsF; K2CO3; [Bmim]BF4 / 8 h / 100 - 110 °C / 200 Torr View Scheme
参考文献
Synthetic Communications, , vol. 34, # 23 p. 4301 - 4311
