(5S,8S,9S,10S,13S,14S,17S)-10,13-二甲基-4,5,6,7,8,9,11,12,14,15,16,17-十二氢-3H-环戊烯并[a]菲-17-醇 合成路线 （共 2 条）
894-65-5 (5S,8S,9S,10S,13S,14S,17S)-10,13-二甲基-4,5,6,7,8,9,11,12,14,15,16,17-十二氢-3H-环戊烯并[a]菲-17-醇
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反应条件
反应条件
1: 93 percent / pyridine / 0.5 h / steam bath 2: 91.1 mg / tert-butyl chromate reagent, glacial AcOH, Ac2O / tetrachloroethene / 0.75 h / 86 - 88 °C 3: hydrogen / 10percent Pd on carbon / ethyl acetate / 0.75 h / Ambient temperature; atmospheric pressure 4: 1.) perchloric acid, acetic anhydride, 2.) bromine, epichlorohydrine / 1.) ethyl acetate, room temperature, 15 min, 2.) CCl4, 0 deg C, 10 min 5: 1.) semicarbazide hydrochloride, sodium acetate, 2.) aq. pyruvic acid / 1.) dioxane, water, room temperature, 2 h, 2.) overnight View Scheme
参考文献
Gravestock, Michael B.; Morton, Douglas R.; Boots, Sharon G.; Johnson, William S.
894-65-5 (5S,8S,9S,10S,13S,14S,17S)-10,13-二甲基-4,5,6,7,8,9,11,12,14,15,16,17-十二氢-3H-环戊烯并[a]菲-17-醇
→
反应条件
反应条件
1: 93 percent / pyridine / 0.5 h / steam bath 2: 91.1 mg / tert-butyl chromate reagent, glacial AcOH, Ac2O / tetrachloroethene / 0.75 h / 86 - 88 °C 3: hydrogen / 10percent Pd on carbon / ethyl acetate / 0.75 h / Ambient temperature; atmospheric pressure View Scheme
参考文献
Gravestock, Michael B.; Morton, Douglas R.; Boots, Sharon G.; Johnson, William S.
