(R)-5-(1-((叔丁氧基羰基)氨基)乙基)异噁唑-3-羧酸合成路线 （共 2 条）
反应条件
1: (R)-5-(1-(tert-butoxycarbonylamino)ethyl)isoxazole-3-carboxylic acid With triethylamine; isobutyl chloroformate in tetrahydrofuran T=-20°C; 1 h; 2: 4-(trifluoromethyl)-1,2-phenylenediamine in tetrahydrofuran T=-20 - 20°C; 4 h; 3: With water; sodium carbonate; acetic acid more than 3 stages;
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 88 ;
US 20090036419 A1
反应条件
1: With lithium hydroxide; water in tetrahydrofuran
T=20°C; 1 h;
2: With hydrogenchloride; water
pH=2;
参考文献
Sunesis Pharmaceuticals, Inc
Patent: US2009/5359 A1, 2009 ;
Location in patent: Page/Page column 42-43 ;
US 20090005359 A1
