9-甲基-9H-咔唑-3-羧酸合成路线 （共 13 条）
反应条件
sodium hydroxide; potassium carbonate in aqueous MeOH; acetone
参考文献
Neurogen Corporation
Patent: US6175015 B1, 2001 ;
US 6175015 B1
反应条件
sodium hydroxide in aqueous MeOH; acetone
参考文献
Neurogen Corporation
Patent: US5892041 A1, 1999 ;
反应条件
potassium tert-butylate; oxygen in N,N-dimethyl-formamide T=25°C; 2 h;
参考文献
Kamiya, Isao; Sugimoto, Takashi
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 1 p. 25 - 30
反应条件
sodium hydroxide in methanol 0.5 h; Heating;
参考文献
Plekhanova; Ovchinnikov; Glibin
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 3 p. 372 - 376
反应条件
1.1: 58 percent / BaCO3 / 140 - 150 °C 2.1: 91 percent / H2 / Pd/C / methanol / 20 °C / atmospheric pressure 3.1: NaNO2 / aq. HCl; H2O / 0.17 h / 0 °C 3.2: 72 percent / Cu / 20 - 70 °C 4.1: 90 percent / NaOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 40, # 3 p. 372 - 376
反应条件
1.1: 58 percent / BaCO3 / 140 - 150 °C 2.1: 91 percent / H2 / Pd/C / methanol / 20 °C / atmospheric pressure 3.1: NaNO2 / aq. HCl; H2O / 0.17 h / 0 °C 3.2: 72 percent / Cu / 20 - 70 °C 4.1: 90 percent / NaOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 40, # 3 p. 372 - 376
反应条件
1.1: 91 percent / H2 / Pd/C / methanol / 20 °C / atmospheric pressure 2.1: NaNO2 / aq. HCl; H2O / 0.17 h / 0 °C 2.2: 72 percent / Cu / 20 - 70 °C 3.1: 90 percent / NaOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 40, # 3 p. 372 - 376
反应条件
1.1: 71 percent / H2 / Pd/C / methanol / 20 °C / atmospheric pressure 2.1: NaNO2 / aq. HCl; H2O / 0 °C 2.2: 70 percent / Cu / 20 - 70 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 40, # 3 p. 372 - 376
反应条件
1: 45 percent / AlCl3 / benzene / 24 h / 25 - 30 °C 2: 86 percent / t-BuOK, O2 / dimethylformamide / 2 h / 25 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 54, # 1 p. 25 - 30
反应条件
1: 87 percent / benzene / 4.5 h / Heating 2: 70 percent / benzene / 8 h / Heating 3: 55 percent / Potassiumhydroxide (6percent) / 1.5 h / Heating 4: lead tetraacetate / dimethylsulfoxide; pyridine / 15 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 22, # 10 p. 1004 - 1010
