1: With triethylamine; methyl chloroformate in tetrahydrofuran T=0°C; 0.166667 h; 2: With sodium tetrahydroborate in water T=0°C; 1 h;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102145 A1, 2013 ;
Location in patent: Paragraph 0290 ;