2-(4-二苯甲基哌嗪)乙基乙酰乙酸酯合成路线

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

→

107610-45-7

参考文献

Cho; Ueda; Mizuno; Ishihara; Aisaka; Noguchi
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 2117 - 2121

99-61-6间硝基苯甲醛+

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯+

14205-39-13-氨基巴豆酸甲酯

→

89226-50-6马尼地平

参考文献

Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

→

89226-50-6马尼地平

参考文献

Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

→

89226-75-5盐酸马尼地平

参考文献

Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

→

104305-93-3O3-[2-[4-[二(苯基)甲基]哌嗪-1-基]乙基]O5-甲基2,6-二甲基-4-(3-硝基苯基)吡啶-3,5-二羧酸酯

参考文献

Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

→

89226-75-5盐酸马尼地平

参考文献

Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

674-82-8双乙烯酮+

10527-64-71-二苯基甲基-4-(2-羟基乙基)哌嗪

→

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

参考文献

Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817

10527-64-71-二苯基甲基-4-(2-羟基乙基)哌嗪

→

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

参考文献

Takeda Chemical Industries, Ltd.
Patent: US4603135 A1, 1986 ;

10527-64-71-二苯基甲基-4-(2-羟基乙基)哌嗪

→

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯+

90096-34-7

参考文献

Takeda Chemical Industries, Ltd.
Patent: US4892875 A1, 1990 ;

841-77-0二苯甲基哌嗪

→

89226-49-32-(4-二苯甲基哌嗪)乙基乙酰乙酸酯

参考文献

Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817