5’-氯-5’-脱氧腺苷合成路线 （共 15 条）
反应条件
1: With pyridine; thionyl chloride in acetonitrile T=0 - 20°C; 2: With ammonium hydroxide T=20°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 18 p. 8066 - 8074,9
反应条件
methanol; water T=20°C;
参考文献
European Journal of Organic Chemistry, , # 24 p. 4748 - 4751
反应条件
ammonium hydroxide in methanol; water 0.5 h; Ambient temperature;
参考文献
Canadian Journal of Chemistry, , vol. 69, # 9 p. 1468 - 1474
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1197 - 1204
反应条件
lithium triethylborohydride in tetrahydrofuran; dimethyl sulfoxide Ambient temperature;
参考文献
Canadian Journal of Chemistry, , vol. 69, # 9 p. 1468 - 1474
反应条件
1: 61 percent / aq. NaOH / 2 h / 100 °C 2: human placental AdoHcy hydrolase / 0.08 h / 37 °C View Scheme
参考文献
Miles, Robert W.; Nielsen, Lars P. C.; Ewing, Gregory J.; Yin, Daniel; Borchardt, Ronald T.; Robins, Morris J.
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8258 - 8260
反应条件
1: 80 percent / hydrogen chloride / acetone; dimethylformamide / Ambient temperature 2: liquid ammonia / 5 h / Heating 3: 92.5 percent / 0.1 M sulfuric acid / 40 °C / overnight View Scheme
参考文献
Holy, Antonin; Rosenberg, Ivan
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1514 - 1518
反应条件
sodium hydroxide T=100°C; 2 h;
参考文献
Miles, Robert W.; Nielsen, Lars P. C.; Ewing, Gregory J.; Yin, Daniel; Borchardt, Ronald T.; Robins, Morris J.
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8258 - 8260
反应条件
1: 80 percent / hydrogen chloride / acetone; dimethylformamide / Ambient temperature 2: liquid ammonia / 5 h / Heating 3: 75.5 percent / 0.1 M sulfuric acid / 40 °C / overnight View Scheme
参考文献
Holy, Antonin; Rosenberg, Ivan
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1514 - 1518
反应条件
sodium hydride in N,N-dimethyl-formamide -30 deg C to r.t., overnight;
参考文献
Robins; Hansske; Wnuk; Kanai
Canadian Journal of Chemistry, 1991 , vol. 69, # 9 p. 1468 - 1474
