1-甲基-1H-吡唑-3-羧酰胺合成路线 （共 5 条）
反应条件
1: With borane-THF in tetrahydrofuran T=65°C; 18 h; 2: With hydrogenchloride; methanol; water in tetrahydrofuran
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82861 A2, 2003 ;
Location in patent: Page/Page column 50-51 ;
WO 03/082861 A2
反应条件
trichlorophosphate in pyridine T=-5°C; 2 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1209 - 1216
反应条件
1: With borane-THF in tetrahydrofuran T=65°C; 18 h; 2: With hydrogenchloride; methanol; water in tetrahydrofuran
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82861 A2, 2003 ;
Location in patent: Page/Page column 50-51 ;
WO 03/082861 A2
反应条件
potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C; 72 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82861 A2, 2003 ;
Location in patent: Page/Page column 50 ;
WO 03/082861 A2
反应条件
ammonium hydroxide
Ambient temperature;
参考文献
Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; Mendoza, Javier de; Martin, M. Rosario
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1209 - 1216
