7-溴-3,4-二氢-2H-异喹啉-1-酮合成路线 （共 5 条）
反应条件
1: With hydrogen bromide in water; acetonitrile T=0°C; 0.5 h; 2: With sodium nitrite in water; acetonitrile T=0°C; 0.9 h; 3: With copper(I) bromide in water; acetonitrile T=0 - 70°C; 1.66667 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122258 A1, 2007 ;
Location in patent: Page/Page column 76 ;
反应条件
sodium azide; methanesulfonic acid in dichloromethane T=0 - 20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2010/160303 A1, 2010 ;
Location in patent: Page/Page column 36 ;
US 20100160303 A1
反应条件
phosphorous pentoxide; trichlorophosphate 2 h; Reflux;
参考文献
Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555
反应条件
1: Reflux 2: oxalyl dichloride / dichloromethane 3: anhydrous iron chloride / -20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 14 p. 4255 - 4258
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dimethyl sulfoxide T=90°C; Suzuki Coupling; 5 h; Inert atmosphere;
参考文献
Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555
