4,4-二氟-3-氧代丁酸甲酯合成路线 （共 4 条）
反应条件
Lawesson's reagent; sulfur in toluene Heatingfurther reagent tetraphosphorus decasulfide;
参考文献
Bodrov, M. B.; Saloutin, V. I.; Pashkevich, K. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 4 p. 799 - 804
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 4 p. 879 - 884
反应条件
1: in methanol
T=60°C; 3 h; Heating / reflux;
2: With hydrogenchloride in methanol; water
T=0°C;
参考文献
SYNGENTA PARTICIPATIONS AG
Patent: WO2006/5612 A1, 2006 ;
Location in patent: Page/Page column 7-8 ;
反应条件
hydrogen sulfide; triphenylphosphine in toluene
2 h; Heating;
参考文献
Bodrov, M. B.; Saloutin, V. I.; Pashkevich, K. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 4 p. 799 - 804
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 4 p. 879 - 884
反应条件
bromine in pyridine; chloroform
-78 deg C -> 20 deg C; 55 - 60 deg C, 4 h;
参考文献
Saloutin, V. I.; Skryabina, Z. E.; Rudaya, M. N.; Pashkevich, K. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1016 - 1022
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1106 - 1114
