7,8-二氟苯并二氢吡喃-4-酮合成路线 (共 3 条)
反应条件
methanesulfonic acid; sulfuric acid T=20°C;
参考文献
Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Lee, Chih-Hung; Brown, Brian S.; Jinkerson, Tammie K.; Koenig, John R.; Daanen, Jerome F.; Latshaw, Steven P.
Patent: US2006/128689 A1, 2006 ;
Location in patent: Page/Page column 44 ;
反应条件
P2O5; methanesulfonic acid T=80°C; 0.0833333 h;
参考文献
EP2518064 A1, ;
Page/Page column 57 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Cooling with ice 1.2: 2 h / 20 °C / Cooling with ice 2.1: P2O5; methanesulfonic acid / 0.08 h / 80 °C View Scheme