1,3-二乙基-5-亚硝基-6-氨基脲嘧啶合成路线 （共 6 条）
反应条件
sodium nitrite in acetic acid T=50 - 60°C; 0.25 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1.1: Ac2O / 70 °C 2.1: aq. AcOH / 0.5 h / 75 °C 2.2: NaNO2 / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3682 - 3692
反应条件
1: acetic acid / 2 h / 80 °C 2: sodium nitrite / acetic acid / 0.25 h / 50 - 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3427 - 3433
反应条件
ammonium hydroxide; sodium dithionite in water 0.5 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 80 percent / NH3; sodium dithionite / H2O / 60 °C 2: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 3: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 80 percent / NH3; sodium dithionite / H2O / 60 °C 2: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 3: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C 4: 95 percent / potassium carbonate / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
