bis(acetylacetonate)nickel(II) in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.5 h;

1: 5-bromo-thiophene-2-carboxylic acid ethyl ester With diisobutyl-aluminum chloride in tetrahydrofuran T=-78°C; Inert atmosphereSchlenk technique; 2: With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphereSchlenk technique; 3: 2-thiophenoyl chloride With CuCN*2LiCl in tetrahydrofuran; hexane T=-40 - 25°C; Inert atmosphere;