1: trans-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide With lithium chloride; (S)-(-)-1,1'-bi-(2-naphthyloxy)(diisopropoxy)titanium in tetrahydrofuran T=18 - 25°C; 0.0833333 h; 2: Brassard's diene in tetrahydrofuran T=0 - 25°C; 42.17 h; 3: With hydrogenchloride in tetrahydrofuran; water T=0°C; Product distribution / selectivity;