反应条件
1: 2,4-dihydroxy-benzoic acid With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; 1 h;
2: benzyl bromide in N,N-dimethyl-formamide; mineral oil
T=20°C; 7 h;
3: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil
pH=1 - 3; regioselective reaction;
参考文献
Fan, Xing; Zhang, Feng-Hua; Al-Safi, Rasha I.; Zeng, Li-Fan; Shabaik, Yumna; Debnath, Bikash; Sanchez, Tino W.; Odde, Srinivas; Neamati, Nouri; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4935 - 4952