反应条件
1: 2-amino-3-[6-bromo-2(1H)-quinolon-4-yl]propionic acid; 2-amino-3-lt;2-(1H)-quinolinon-4-ylgt;propionic acid hydrochloride With sodium hydroxide; hydrogen; Raney nikel in water T=20°C; 2 h; 2: 4-chloro-benzoyl chloride With sodium hydroxide in water; acetone T=0°C; 3: With hydrogenchloride in water; acetone
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2006/59781 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;