2-苯基-1H-咪唑-4,5-二甲酸合成路线 （共 10 条）
反应条件
bei der Destillation;
参考文献
Maquenne
Annales de Chimie (Cachan, France), 1891 , vol. <6> 24, p. 534
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1890 , vol. 111, p. 115
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Maquenne
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1890 , vol. 111, p. 741,742
Annales de Chimie (Cachan, France), 1891 , vol. <6> 24, p. 543
反应条件
1: 2,3-dinitroxybutanedioic acid With ammonium hydroxide
cooling;
2: benzaldehyde in water
T=-4 - 0°C; 20 h; Further stages.;
参考文献
Lebedev; Lebedeva; Sheludyakov; Kovaleva; Ustinova; Shatunov
Russian Journal of General Chemistry, 2007 , vol. 77, # 5 p. 949 - 953
反应条件
ammonium hydroxide
T=0°C; 20 h; Yield given;
参考文献
Anderson, Wayne K.; Bhattacharjee, Debkumar; Houston, D. Michael
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 119 - 127
参考文献
Hinkel; Richards; Thomas
Journal of the Chemical Society, 1937 , p. 1432,1436
反应条件
1: aqueous NaOH
2: K2cr2O7; aqueous H2SO4
View Scheme
参考文献
Murata
Bulletin of the Chemical Society of Japan, 1959 , vol. 32, p. 841,844
反应条件
1: aqueous NaOH
2: K2cr2O7; aqueous H2SO4
View Scheme
参考文献
Murata
Bulletin of the Chemical Society of Japan, 1959 , vol. 32, p. 841,844
反应条件
potassium dichromate; sulfuric acid
参考文献
Murata
Bulletin of the Chemical Society of Japan, 1959 , vol. 32, p. 841,844
参考文献
Maquenne
Annales de Chimie (Cachan, France), 1891 , vol. <6> 24, p. 534
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1890 , vol. 111, p. 115
Full Text Show Details
Maquenne
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1890 , vol. 111, p. 115,741
反应条件
1: nitros gases; diethyl ether
2: ethanolic NaOH
View Scheme
参考文献
Hinkel; Richards; Thomas
Journal of the Chemical Society, 1937 , p. 1432,1436
反应条件
1: With sulfuric acid
20 h; Heating / reflux;
2: With sodium hydroxide in methanol
T=0°C; pH=~ 7;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/42537 A1, 2005 ;
Location in patent: Page/Page column 73 ;
WO 2005/042537 A1
