5-硝基噻吩-3-羧酸甲酯合成路线 （共 8 条）
参考文献
Rinkes
Recueil des Travaux Chimiques des Pays-Bas, 1934 , vol. 53, p. 643,648
Recueil des Travaux Chimiques des Pays-Bas, 1936 , vol. 55, p. 991
反应条件
nitric acid; acetic anhydride in acetic acid
T=0 - 40°C; 1 h;
参考文献
F2G LTD
Patent: WO2006/123145 A1, 2006 ;
Location in patent: Page/Page column 44 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/156614 A2, 2008 ;
Location in patent: Page/Page column 130-131 ;
WO 2008/156614 A2
参考文献
Lange, Udo E.W.; Backfisch, Gisela; Delzer, Juergen; Geneste, Herve; Graef, Claudia; Hornberger, Wilfried; Kling, Andreas; Lauterbach, Arnulf; Subkowski, Thomas; Zechel, Christian
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 10 p. 1379 - 1382
反应条件
1: sulfuric acid
2: nitric acid; acetic acid anhydride / -10 °C
View Scheme
参考文献
Rinkes
Recueil des Travaux Chimiques des Pays-Bas, 1934 , vol. 53, p. 643,648
Recueil des Travaux Chimiques des Pays-Bas, 1936 , vol. 55, p. 991
反应条件
in benzene
T=160°C; Diels-Alder reaction; Cooling with liquid nitrogen;
参考文献
Brasca, Romina; Kneeteman, Maria N.; Mancini, Pedro M.E.; Fabian, Walter M.F.
Journal of Molecular Structure, 2012 , vol. 1010, p. 158 - 168
反应条件
iron in acetic acid
T=75 - 80°C;
参考文献
Gol'dfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1626 - 1629
反应条件
1: 69 percent / Fe / acetic acid / 75 - 80 °C
2: 69 percent / conc.HCl / Heating
View Scheme
参考文献
Gol'dfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1626 - 1629
