(R)-3-氨基-2-哌啶酮合成路线 （共 9 条）
反应条件
1: SOCl2 / 14 h / Ambient temperature 2: H2O / 50 - 60 °C / brief heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 5 p. 1329 - 1334
参考文献
WO2005/75439 A1, ;
Page/Page column 129 ;
WO 2005/075439 A1
反应条件
sodium methylate in methanol T=20°C; 1 - 8 h;
参考文献
WO2004/98589 A1, ;
Page 163 ;
WO 2004/098589 A1
反应条件
aluminum oxide; sodium hydroxide in toluene 1.5 h; Heating;
参考文献
Hutchinson, Ian S; Matlin, Stephen A; Mete, Antonio
Tetrahedron, 2002 , vol. 58, # 16 p. 3137 - 3143
反应条件
in water T=50 - 60°C; brief heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 5 p. 1329 - 1334
反应条件
potassium phosphate buffer; pyridoxal 5'-phosphate in water T=37°C; α-amino-ε-caprolactam racemase from Achromobacter obae, pH 8; other pH values; Michaelis constant and Vmax determination;
参考文献
Agricultural and Biological Chemistry, , vol. 47, # 5 p. 1149 - 1150
反应条件
sodium hydroxide T=25°C; pH 11,5-12,8; competitive reaction with 2,4-Dab Me; Rate constantKineticsProduct distribution;
参考文献
Tetrahedron Letters, , vol. 35, # 2 p. 281 - 284
反应条件
triethylamine in dichloromethane
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230414 A1, 2011 ;
US 20110230414 A1
反应条件
in chloroform Yield given;
参考文献
Toshima, Hiroaki; Maru, Kazuko; Saito, Masatoshi; Ichihara, Akitami
Tetrahedron, 1999 , vol. 55, # 18 p. 5793 - 5808
