5-甲氧基苯并咪唑-2-甲酸合成路线 (共 3 条)
反应条件
1: With sodium hydroxide; potassium permanganate in water 1 h; Heating / reflux; 2: With acetic acid in water pH=4;
参考文献
US2006/111416 A1, ;
Page/Page column 11 ;
US 20060111416 A1
反应条件
lithium hydroxide in tetrahydrofuran; water T=160°C; 4 h; microwave irradiation;
参考文献
Cai, Tingwei Bill; Zou, Zhou; Thomas, James B.; Brieaddy, Larry; Navarro, Hernan A.; Carroll, F. Ivy
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1849 - 1860
反应条件
1: T=80°C; 2: With sodium hydroxide in 1,4-dioxane T=200°C; microwave irradiation; Further stages.;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 23 p. 6633 - 6637